Freedman,+Stacie1

Fluoxetine Structural Formula: C17H18F3NO Molar Mass: 309.3 grams per mol pH: 4.35 in a saturated solution Solubility: 50mg per mL of water Melting Point: 157.5 degrees C Boiling Point: Reactivity: Uses: > >
 * When taken with Ibuprofen for a long period of time can cause GI bleeding
 * Having liver failure results in a slower rate of metabolizing the Fluoxetine causing an increase in exposure to the drug
 * Should not take if taking pimozide, thioridazine, or an MAO inhibitor or fatal reactions may occur
 * Antidepressant
 * Approved to treat major depression, OCD, eating disorders, panic disorder, and anxiety disorders
 * Available through prescription only
 * When serotonin is released from the "sending" nerve cell, the leftover serotonin is normally reabsorbed by an uptake pump
 * By blocking the uptake pump, Prozac increases the amount of active serotonin that can be delivered to the "receiving" nerve cell
 * This means that the neurons steep for a longer period of time in the serotonin you already produce
 * Prozac selectively affects only serotonin which is why Prozac and other similar drugs are called **selective serotonin reuptake inhibitors,** or SSRIs
 * The drug blocks the sensor on the axon that tells the cell when enough serotonin has been produced
 * This causes the axon to release even more serotonin
 * over a period of 2-3 weeks, the receiving cell becomes more sensitive to serotonin, and this is the point at which the anti-depressant effect becomes experienced by the patient

How Prozac is Synthesized:
 * The compound synthesized is (°)-N,N-dimethyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, or "N-methyl Prozac" (NMP)
 * The synthesis of NMP requires one two-hour period and a second three-hour period
 * In the first period, a common Mannich base, 3-dimethylaminopropiophenone, is reduced with sodium borohydride to form (°)-3-dimethylamino-1-phenylpropanol
 * In the second period, potassium t-butoxide is used to couple (°)-3-dimethylamino-1-phenylpropanol with p-chlorotrifluoromethylbenzene to form NMP, which is isolated as its oxalate salt.

Works cited: http://en.wikipedia.org/wiki/Fluoxetine http://www.drugs.com/fluoxetine.html http://adsabs.harvard.edu/abs/1998JChEd..75.1266P http://www.brainphysics.com/howprozacworks.php

Stacie, It was very good and informative, but you never really addressed the picture of the tomato... I was kind of curious about what the significance of that is, but other than that I enjoyed learning about how Prozac is an SSRI and how it's synthesized. atta girl! :)

okay so I just saved what i wrote and looked at the page again and there was a picture of cigarettes instead of the tomatoes!! Either I'm going crazy or the picture changed... I'm not sure which.