Karkhanis,+Parag1

=Ibuprofen=



Ibuprofen is the shortened name for iso-butyl-propanoic-phenolic acid. It is the active ingredient in Advil, Motrin, and the lesser-known Nurofen. Its pain relieving properties help with arthritis, dysmenorrhea, fevers, and aches and pains in general. The structural formula of Ibuprofen is C13H18O2. == ==

U ses
Ibuprofen is used in over-the-counter medicines Advil and Motrin. Ibuprofen works by inhibiting the enzyme cyclooxygenase, which is an enzyme in the path that creates prostoglandins, or the body’s pain indicators. This reduces pain that is not too serious. Advil and Motrin are two of the most popular brands of pain reliever, and their active ingredients are Ibuprofen. Ibuprofen is known for it's relatively low rate of adverse reactions to the user, so it is almost universally accepted as the go-to-painkiller.

Major Sources of Extracton
The major method of Ibuprofen manufacturing was discovered in 1997, and is significantly cheaper than the previous method.



Chemical and Physical Properties
Ibuprofen is only slightly soluble. Less than 1 mg of ibuprofen dissolves in 1 mg of water. It is significantly more soluble in alcohol and water mixtures than pure water. This makes it dissolve in organic solvents more easily, which serves its purpose as a pain reliever. Ibuprofen is a solid at room temperature, and the melting point is 76 degrees Celsius. The molar mass is 206.28g. Ibuprofen appears as a white, crystalline powder in its pure form. When combusted, it breaks down into CO2 and CO.

Chemical structure of Ibuprofen

This piece of art shows a dog in need of some Ibuprofen!

Critic- 1. Interesting facts, not many people would've known about the Nurofen, therefore learning something new :) 2. It's good to know that the synthesis of the drug got cheaper in 1997, probably why these drugs are very affordable. 3. It would have been interesting to read about some side effects of taking the drug. 4. Humorous caption on the last picture, adds good style to the page. 5. A mention about long term effects such as liver or heart problems could have been beneficial.

Michelle Chu

Sources:

http://upload.wikimedia.org/wikipedia/commons/c/cc/BHC_synthesis_of_ibuprofen.png http://en.wikipedia.org/wiki/Ibuprofen http://icep.wikispaces.com/file/view/ibuprofen3.jpg/98483809/ibuprofen3.jpg http://blogs.targetx.com/snhu/ChrisDupuy/Advil.jpg http://bulkpharm.mallinckrodt.com/_attachments/msds/IBUPR.htm